For 42 years, breast cancer researchers and doctors have been gathering in San Antonio every year to review the latest research at the eponymous San Antonio Breast Cancer Symposium (SABCS). Thousands of people from countless subspecialties each bring their unique lens to a disease that affects increasing numbers of people around the world. It’s a big conference with a lot of information. And it’s full of dense insider speak – which reminds me that I once heard that obscure medical terminology was developed at a time when doctors routinely kept patients in the dark about their conditions.
Over the years more patient advocates have come to SABCS, but most of us don’t have backgrounds in medicine, biology, oncology, epidemiology, or other related fields. Sometimes people ask me to explain the alphabet soup of acronyms and medical terms that are commonly used by SABCS presenters and participants.
In order to fully understand the data presented at SABCS, it’s helpful to understand the different endpoints that get used in breast cancer trials—endpoints being what’s measured in a particular trial. Different endpoints tell us different things about the effectiveness of experimental breast cancer treatments.
The number one way most people judge a cancer treatment is if it helps them live longer, that is, if it improves survival. But that’s not always what researchers study and so it can be hard to know what different kinds of data really means for patients. I created a Twitter thread to help explain commonly used endpoints that are the primary outcomes measured by a clinical trial, and it got so much positive response, I thought I’d share it here, too.
Clinical endpoints are outcomes that demonstrate direct benefit to patients and include things like survival, the absence of disease, and decreased pain. Survival is a paramount clinical endpoint for most people with breast cancer and may be studied in different ways.
Because survival data can take a long time, making a study expensive, surrogate endpoints are often used as a substitute for clinical endpoints, providing an intermediate measure of the likely effects of a specific treatment. Surrogate endpoints are meaningful for researchers and may provide useful indication that the research hypothesis is on track, but they do not always correlate with real clinical endpoints that benefit patients.
From the patient side, most people want to know they don’t have cancer after treatment.
Of course there are many other factors that matter to patients as they weigh their treatment options. That’s why, as SABCS got underway, I tweeted out a quick—and no doubt incomplete—list of some of the questions I’ll be asking during the conference, in no particular order:
What matters to you? What do you want to know about new proposed treatments? How do you evaluate breast cancer research? What’s important to you?